In contrast to other commonly used biomarkers such as cardiac troponins and N-terminal proB-type natriuretic peptide (NT-proBNP), secretoneurin (SN) is associated with biological processes linked to heart cell calcium handling, a key mechanism in the regulation of heart rhythm and has been described as the “missing link biomarker” in cardiovascular disease risk assessment. This unique biological function may explain why SN has been shown to be an independent and strong predictor of mortality in all major patient cohorts tested, including patients with chronic heart failure, ventricular arrhythmia, acute heart failure, and acute respiratory failure patients with CVD and severe sepsis.
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