Growth Factor

Growth factors are soluble-secreted signaling polypeptides capable of instructing specific cellular responses in a biological environment. The specific cellular response trigged by growth factor signaling can result in a very wide range of cell actions, including cell survival, and control over migration, differentiation or proliferation of a specific subset of cells. They also play important roles in the maintenance of tissue homeostasis and wound healing in the adult. Their activities are mediated via binding to transmembrane receptors that often contain cytoplasmic tyrosine kinase domains. When unregulated, many growth factors and their receptors have been implicated in tumor formation. In summary the system of Growth Hormone and the Insulin-like Growth Factors with their Binding Proteins is an important control cycle.